Succinic acid in aesthetic treatments
Succinic acid and its salts, including sodium succinate, are discussed as ingredients in some HA-based skin treatments. Succinic acid participates in cellular metabolism, but a substance occurring in the body does not establish that injecting a particular preparation is beneficial or appropriate.
What the label does not tell you
A 2025 study of HA plus succinic acid reported changes in cultured human skin cells and adipocytes. It was a laboratory study with industry-employed authors; its authors expressly called for future clinical studies. It cannot establish the degree of visible improvement, treatment durability or patient safety. Evidence for the complete formulation should also distinguish the contribution of succinic acid from HA, the procedure itself and other ingredients.
Questions to bring
Does the formulation contain succinic acid or a succinate salt and what else is in it? Which controlled human studies support this exact injectable and intended result? What is authorised locally for this preparation and route? What uncertainty, side effects and alternatives should I consider before choosing it?
Evidence and scope
Biological plausibility and cell-culture results are not established clinical efficacy. This research does not justify a claim that the treatment reverses ageing or restores facial fat.
Read the original sources
Sources describe specific products, studies or countries. They do not establish approval everywhere.
General education. Your clinician can assess your individual suitability. Rules depend on the treatment country; FDA references concern the United States. External sources may be in another language.